Immunisation is one of the most effective public health interventions in reducing morbidity and mortality from infectious diseases. However, vaccine preventable diseases still occur in Australia despite ready access to safe and effective vaccines. This can lead to increased use of GP services, time away from school and work, hospitalisation, disability, and premature death. WA Primary Health alliance aims to improve childhood immunisation rates and immunisation coverage in a wider context such as preventable hospital admissions (influenza and pneumococcal disease in children and the elderly as well as pertussis), in Aboriginal Health (timeliness of immunisation and adult immunisation) as well as Aged Care and Population Health (vulnerable populations, chronic disease, outbreaks of vaccine preventable diseases and epidemics).